Science Wednesday : Hi reddit , we ’ re Hui - Chen Lu , Yousuf Ali , Hunter Allen and we found that people with the NMNAT 2 protein had greater resistance to cognitive decline
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چکیده
Hui-Chen, Yousuf, and Hunter: The need of biomarkers to detect at AD at an early age (hopefully, when disease progression can be slowed or stopped) is an obvious one. Currently a lot of scientific research is ongoing to identify AD biomarkers. The Alzheimer’s Association website (http://www.alz.org/research/science/alzheimers_prevention_and_risk.asp) has a good discussion on lifestyle changes and other approaches to decrease AD risk. Because of our preliminary finding that caffeine increases NMNAT2 levels and the epidemiological association between moderate caffeine intact and lower dementia risk, we are all drinking coffee and tea.
منابع مشابه
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein levels are reduced. NMNAT2 shifts its solubility and colocalizes with aggregated Tau in AD brains...
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متن کاملNicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.
Active zones are specialized presynaptic structures critical for neurotransmission. We show that a neuronal maintenance factor, nicotinamide mononucleotide adenylyltransferase (NMNAT), is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein, Bruchpilot (BRP), and shielding it from activity-induced ubiquitin-proteasome-mediated degra...
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متن کاملNMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.
Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles. Drosophila models of tauopathy display prominent features of the human disease including compromised lifespan, impairments of learning, memory and locomotor functions and age-dependent neurodegeneration visib...
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تاریخ انتشار 2016